Search for: [Abstract = "Cyclophilins \(CyPs\) constitute a large class of highly conserved, ubiquitousPPlases \(EC 5.2.1.8\) that together with FK560 binding proteins \(FKBP\) and parvulinsbelong to a superfamily of immunophilins. These three classes of proteins areeasily distinguishable by their selective interactions with immunosuppressivedrugs. Cyclophilins are targets for cyclosporin A \(CsA\), parvulins bind juglone\(5\-hydroxy\-l.4\-naphthoquinone\) and FKBP, they are inhibited either by FK560drug or by rapamycin. Despite the lack of structural similarity, all these proteinshave been shown to act as peptidylprolyl cis\-trans isomerases. In all cases, binding of the drug inhibits their PPIase activity. Distinct isoforms of cyclophilinshave been localized in the cytoplasm, nucleus, mitochondria, chloroplasts andendoplasmic reticulum."]

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