@misc{Konieczny_Leszek_Antibodies_2001,
 author={Konieczny, Leszek and Piekarska, Barbara and Roterman, Irena and Rybarska, Janina and Stopa, Barbara and Zemanek, Grzegorz},
 volume={54},
 number={3},
 copyright={Creative Commons Attribution BY-SA 4.0 license},
 journal={Biotechnologia, vol.54, 3 (2001)-.},
 howpublished={online},
 year={2001},
 publisher={Committee on Biotechnology PAS},
 publisher={Institute of Bioorganic Chemistry PAS},
 language={pol},
 abstract={The paper addresses to problems of carriers and antibodies in targetedtherapy. Also the new material ofliquid crystalline nature, designed for use as adrug vehicle in the immune targeting technique is presented and its property isdiscussed. Obtained by self-assembling, the ribbon-like supramolecular organisation products of some azo-dyes, particularly including Congo red and Evansblue, form micellar bodies of this carrier. They bind spontaneously and selectively to immune complexes but not to free antibodies. The binding strongly enhances the antigen - antibody interaction. Micelles ofthe carrier composed ofself-assembled molecules easily incorporate many foreign substances includingdrugs, favouring however those of possibly planar molecules. The excess of carrier leaves the organism rapidly through the urine tract, reducing the possibleside effects. The nature of chromonic liquid crystalline material is suitable formany modifications and adapting elaboration.},
 type={Text},
 title={Antibodies and drug-carriers in targeted therapy - progress and limitations},
 URL={http://rcin.org.pl/Content/138851/PDF/POZN271_174132_biotechnologia-2001-no3-konieczny.pdf},
 keywords={biotechnology},
}