@misc{Galas_Edward_Screening_1995, author={Galas, Edward and Kwapisz, Ewa and Polak, Jacek}, volume={30}, number={3}, copyright={Creative Commons Attribution BY-SA 4.0 license}, journal={Biotechnologia, vol.30, 3 (1995)-.}, howpublished={online}, year={1995}, publisher={Committee on Biotechnology PAS}, publisher={Institute of Bioorganic Chemistry PAS}, language={pol}, abstract={The screening methods used for improvement of industrial strains are presented. Two generalcategories of methods have been distinguished: random screening and rational screening. Majortechniques employed in rational screening are based on the selection of auxotrophic mutants,revertants of non-producers, strains resistant to some factors like toxic analogues of metabolismintermediates, induction and catabolite repression or end-product inhibition, mutants with modified cell wall permeability and microorganisms tolerating some nutrients and precursors ofsecondary metabolites.}, type={Text}, title={Screening methods of industrial strain mutants}, URL={http://rcin.org.pl/Content/147667/PDF/POZN271_183232_biotechnologia-1995-no3-galas.pdf}, keywords={biotechnology}, }