@misc{Koziołkiewicz_Maria_Stability_1994, author={Koziołkiewicz, Maria}, volume={27}, number={4}, copyright={Creative Commons Attribution BY-SA 4.0 license}, journal={Biotechnologia, vol.27, 4 (1994)-.}, howpublished={online}, year={1994}, publisher={Committee on Biotechnology PAS}, publisher={Institute of Bioorganic Chemistry PAS}, language={pol}, abstract={Nucleolytic enzymes (5 - and 3'-nucleases, exo- and endonucleases) can degrade short unmodified oligonucleotides applied as potential antisense agents. Better stability of oligonucleotidesagainst nucleolytic enzymes can be achieved by chemical modification of intemucleotide bonds.Stability of the phosphorothioate, phosphorodithioate and methylphosphonate analogues of oligonucleotides against nuclease PI, 3'-exonuclease, snake venom phosphodiesterase and other nucleases is discussed.}, type={Text}, title={Stability of antisense oligonucieotides— the possibilities of their enzymatic digestion}, URL={http://rcin.org.pl/Content/148130/PDF/POZN271_183639_biotechnologia-1994-no4-koziolkiewicz.pdf}, keywords={biotechnology}, }