@misc{Osetowska_Ewa_Zmiany_1963, author={Osetowska, Ewa and Mossakowski, Mirosław Jan (1929–2001)}, volume={1}, number={1}, copyright={Creative Commons Attribution BY 4.0 license}, address={Warszawa}, journal={Neuropatologia Polska}, howpublished={online}, year={1963}, publisher={Państwowy Zakład Wydawnictw Lekarskich}, language={pol}, abstract={The second case concerns a73-year- old male patient. Uremia was presumably connected with hydronephrosis caused by urinary retention due to prostatic adenomas. The changes in the brain in this case were few, with predominance of edema and moderate atherosclerotic lesions. In the third case, that of a 24-year-old male patient, uremia developed as a result of bilateral destruction of the kidneys by a tuberculous process. The morphological findings in the brain closely resembled those of typical uremic encephalopathy. In all three cases uremia was the result of renal disease, but the pathogenetic mechanism was different in each case. In the opinion of the authors, different pathogenetic mechanisms may be the reason for the different morphological changes in the central nervous system. Other important factors affecting the morphological character of the cerebral changes include duration of the uremic process, intensity of the disorders in the electrolyte and water balance of the body, condition of the nervous tissue at the time ofd evelopment of uremia (age of the patient), and presence of various coexisting factors. In the first case the additional factor consisted in inflammatory changes of the nature of encephalitis allergica, which, according to the authors, is connected with the allergic mechanism of glomerulonephritis. Presumably, various factors coexisting with uremia offer an explanation of the differences and diversity of the clinical neurological pictures of uremia, while the morphological changes in the brain are monotonous and few.}, type={Text}, title={Zmiany w ośrodkowym układzie nerwowym w stanach mocznicowych}, URL={http://rcin.org.pl/Content/70566/PDF/publ_20.pdf}, }