@misc{Matyja_Ewa_Mitochondrial_1996,
 author={Matyja, Ewa and Grieb, Paweł and Ryba, Mirosław and Jagielski, Janusz and Mossakowski, Mirosław Jan (1929–2001)},
 volume={34},
 number={1},
 copyright={Creative Commons Attribution BY 4.0 license},
 address={Warsaw},
 journal={Folia Neuropathologica},
 howpublished={online},
 year={1996},
 publisher={Medical Publishing House},
 language={eng},
 abstract={The effects of 2-chloro-2’-deoxyadenosine (cladribine, 2-CdA) and a closely related compound 2-bromo-2’-deoxyadenosi- ne (2-BdA) on organotypic cultures of human malignant gliomas were studied with the use of electron microscopy. The cultures grown from surgical biopsies included six glioblastomas, three anaplastic astrocytomas and low-grade fibrillary astrocytoma. After 6 to 10 days of the in vitro growth the cultures were exposed to 0.3-10 /iM 2-CdA or 2-BdA for 1 to 10 days. Mitochondrial swelling and disappearance of cristae following exposure to the tested substances were observed, but only in highly anaplastic (low-differentiated) tumor cells. The mitochondrial toxicity was dose- and time-dependent, and no difference was found between the effect of 2-CdA and 2-BdA.},
 type={Text},
 title={Mitochondrial damage following exposure of organotypic cultures of human malignant gliomas to 2-chloro- and 2-bromo-2’-deoxyadenosine},
 URL={http://rcin.org.pl/Content/71872/PDF/publ_257.pdf},
 keywords={glial tumors, cladribine (2-CdA), 2-bromo-2’-deoxyadenosine, organotypic cultures, mitochondrial toxicity},
}