Title:

Prolongation of rabbit -to-dog liver xenograft survival in recpients pretreated with rabbit blood

Creator:

Olszewski, Waldemar ; Łukasiewicz, Hanna

Publisher:

Polska Akademia Nauk

Place of publishing:

Warszawa

Date issued/created:

1973

Type of object:

Journal/Article

Abstract:

An attempt was made to prolong rabbit-to-dog liver graft survival by pretreatment of recipients with donor species blood elements. Recipients were given intraarterially whole blood, washed erythrocytes, erythrocyte stroma, leukocytes, and rabbit plasma 1 hr befor transplantation of rabbit liver. Pretreatment with whole blood or red cells was followed by acute depletion of hemagglutinins, hemolysins, complement, and decrease in platelet and leukocyte counts. Rabbit livers transplanted at that time had a 10—20-fold longer survival time. Pretreatment with donor leukocytes only slightly prolonged graft survival, whereas rabbit plasma had no effect at all. It may be concluded that recipient circulating antibodies agglutinating donor erythrocytes are responsible for triggering the process of hyperacute rejection.

Relation:

Acta Medica Polona

Volume:

14

Issue:

2

Start page:

131

End page:

138

Resource type:

Text

Detailed Resource Type:

Article

Format:

pdf

Language:

eng

Rights:

Creative Commons Attribution BY 4.0 license

Terms of use:

- ; Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at:

Copyright holder:

Olszewski, Waldemar

Digitizing institution:

Mossakowski Medical Research Institute PAS

Original in:

Library of the Mossakowski Medical Research Institute PAS

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open