Object

Title: Files for neuromuscular diseases (2014) - nr 24/14

Creator:

Fidziańska-Dolot, Anna (1930–2015)

Date issued/created:

2014

Resource type:

Text

Contributor:

Mossakowski Medical Research Center Polish Academy of Sciences. Department of Neuromuscular

Place of publishing:

Warsaw

Description:

Muscle segment examination in light & electon microscopy

Abstract:

A 5-month-old patient with suspected myasthenic syndrome was examined. A biopsy of quadricepswas performed. Electronmicroscopy analysis revealed numerous ultrastructural abnormalities ofmuscle fibers with features of immaturity. Local disintegration of myofibrils and swollenmitochondria were observed. Mitochondria were characterized by partial or total lack ofmitochondrial cristae. Massive glycogen depositions were seen (Fig. 1,2). In some part of myocytesloss of myofibrils were visible. Empty areas were filled with homogeneous myofibril-like material(Fig. 3).Multi-shaped nuclei with the characteristic accumulation of heterochromatin and cleavageofthe outer nuclear membrane were observed. Mitochondria were swollen, with blurred cristae andmitochondrial membranes (Fig 4,5,6). Nuclei of irregular shape with clear features of nucleopathy(disrupted nuclear membrane, mitochondria within the nuclei) were seen (Fig 8,9).

Detailed Resource Type:

Photography ; Files

Format:

pdf

Resource Identifier:

oai:rcin.org.pl:110692

Language:

pol

Language of abstract:

eng

Rights:

Creative Commons Attribution BY 4.0 license

Terms of use:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitizing institution:

Mossakowski Medical Research Center PAS

Original in:

Library of the Mossakowski Medical Research Center PAS

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open

Edition name Date
opis nr 24/14 Feb 9, 2021
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