Title:

Files for neuromuscular diseases (2012) - nr 23/12

Creator:

Fidziańska-Dolot, Anna (1930–2015)

Contributor:

Mossakowski Medical Research Center Polish Academy of Sciences. Department of Neuromuscular

Place of publishing:

Warsaw

Date issued/created:

2012

Subject and Keywords:

Muscular dystrophy

Abstract:

A 38-year-old patient with suspected muscular dystrophy was examined. A biopsy of biceps sinister was performed. Electronmicroscopy analysis revealed some fibers of correct diameter and preserved myofibrils structure. Also fibers with normal located under the sarcolemma nuclei but with visible alterations in the miofibrils architecture were seen.In some fibers, multiply centrally located nuclei were visible, and between the fibers abundant connective tissue was present.Numerous muscle fibers of myotube-like morphology, characterized by small diameter and centrally located nuclei, usually single or in number of two were observed. They showed abnormal sarcomeres structure and loss of A line.Intramuscular nerves characterized by the presence of a 2-3-layer myelin sheath resembling the "onion bulb" structure were observe.Microscopic image of the biopsy suggests congenital fiber-type disproportion (CFTS) associated with defect of actin or tropomyosin.

Resource type:

Text

Detailed Resource Type:

Photography ; Files

Format:

pdf

Language:

pol

Rights:

Creative Commons Attribution BY 4.0 license

Terms of use:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitizing institution:

Mossakowski Medical Research Institute PAS

Original in:

Library of the Mossakowski Medical Research Institute PAS

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open