Waleron, Krzysztof ; Nakonieczna, Joanna ; Waleron, Małgorzata ; Podhajska, Anna J.
50 years of studies of restriction - modification systems
Komitet Biotechnologii PAN ; Instytut Chemii Bioorganicznej PAN
The basic function of restriction endonucleases and methyltransferases is protection of the host genome against foreign DNA. Their recombination and transposition related functions are still being discussed. Some authors postulate that R-M genes may act as selfish genetic elements. Restriction endonucleases are indispensable tools in molecular biology. As these enzymes recognize DNA sequence very specifically, they serve as a model for protein-DNA interaction. Restriction-modification genes have also played the same role as a model for evolutionary studies as well as protein structure - function relations. So far, there have been more than 3500 bacterial strains studied which possessed R-M genes of more than 280 different specificities towards recognition sequence and cleavage sites. They became a very good commercial product for many biotechnological companies. At present, in a genome sequencing era, R-M genes seem to be much more common than it was thought before.
Biotechnologia, vol.73, 2 (2006)-.
0860-7796 ; oai:rcin.org.pl:87551 ; IChB B-69
Biblioteka Instytutu Chemii Bioorganicznej PAN
Licencja Creative Commons Uznanie autorstwa-Na tych samych warunkach 4.0
Instytut Chemii Bioorganiczneji Polskiej Akademii Nauk
Instytut Chemii Bioorganiczneji Polskiej Akademii Nauk
2 paź 2020
11 gru 2019
954
https://rcin.org.pl/publication/114195
Nazwa wydania | Data |
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Systemy restrykcyjno-modyfikacyjne - 50 lat badań | 2 paź 2020 |
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