Jasiński, Adam ; Słomski, Ryszard ; Szalata, Marlena ; Lipiński, Daniel
The organ transplantation - a challenge for biotechnology
Komitet Biotechnologii PAN ; Instytut Chemii Bioorganicznej PAN
The use of animals as a source of organs and tissues for xenotransplantation can overcome the growing shortage of human organ donors. However, xenoreactive antibodies present in humans directed against swine Gal antigen on the surface of xenograft donor cells leads to the complement activation and immediate xenograft rejection as a consequence of hyperacute immunological reaction. The graft of genetically modified organ of a swine would be tolerated with simultaneous administration of medicines decreasing other less severe immunological reactions. This review summarizes the clinical history and rationale for xenotransplantation, recent progress in understanding the physiologic, immunologic, and infectious obstacles to xenotransplantation and some of the strategies being pursued to overcome these dificulties.
Biotechnologia, vol.72, 1 (2006)-.
0860-7796 ; oai:rcin.org.pl:87761 ; IChB B-68
Biblioteka Instytutu Chemii Bioorganicznej PAN
Licencja Creative Commons Uznanie autorstwa-Na tych samych warunkach 4.0
Instytut Chemii Bioorganiczneji Polskiej Akademii Nauk
Instytut Chemii Bioorganiczneji Polskiej Akademii Nauk
2 paź 2020
13 gru 2019
743
https://rcin.org.pl/publication/114728
Nazwa wydania | Data |
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Transplantacja narządów - wyzwanie dla biotechnologii | 2 paź 2020 |
Tyczewska, Agata Bąkowska- Żywicka, Kamila
Pieczyński, Marcin Bielewicz, Dawid Dolata, Jakub Szweykowska-Kulińska, Zofia