Object

Title: Glucosyltransferases and glucans of mutans streptococci as virulencefactors in the pathogenesis of dental caries

Creator:

Wiater, Adrian ; Szczodrak, Janusz

Date issued/created:

2003

Resource type:

Text

Subtitle:

Glucosyltransferases and glucans of mutans streptococci as virulencefactors in the pathogenesis of dental caries

Publisher:

Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS

Description:

prace przeglądowe

Abstract:

Mutans streptococci Streptococcus mutans and S. sobrinus play central role inthe etiology of human dental caries due to their acidogenic potential and abilityto form extracellular water-insoluble and water-soluble glucans in the presenceof dietary sucrose. Streptococcal glucans are synthesized by a constitutive groupof extracellular and/or cell-associated enzymes showing glucosyltransferase(GTF) activity. Each enzyme has distinctive properties, varying in its requirement for a glucan primer molecule, the proportion of a(l-6)- and a(l-3)-linkages, the degree of branching it introduces into the glucan, and the total lengthofglucan chain produced. Moreover, the overall properties ofglucan depend onthe relative activity of different GTF enzymes, as well as on their interactions,since one GTF may modify the product of another. This review article presentsrecent trends in the investigations on streptococcal GTFs and glucans. Particular emphasis has been laid on catalytic properties and molecular structure ofdifferent GTFs and on the mechanism of synthesis of specific glucans. Furthermore, the role of these enzymes and their products in the pathogenesis of dental caries is also discussed.

Relation:

Biotechnologia, vol.62, 3 (2003)-.

Volume:

62

Issue:

3

Start page:

193

End page:

206

Detailed Resource Type:

Article

Format:

application/pdf

Resource Identifier:

0860-7796 ; oai:rcin.org.pl:133319 ; IChB B-58

Source:

Library of Institute of Bioorganic Chemistry PAS

Language:

pol

Language of abstract:

eng

Temporal coverage:

1988-2010

Rights:

Creative Commons Attribution BY 4.0 license

Terms of use:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at:

Digitizing institution:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Original in:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open

Object collections:

Last modified:

Oct 2, 2020

In our library since:

Jul 23, 2020

Number of object content hits:

17

All available object's versions:

https://rcin.org.pl/publication/167982

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