Subtitle:

From neoplastic neural development to gene therapy of brain tumors -IGF-I antisense and triple helix approaches

Publisher:

Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS

Abstract:

IGF-I, insulin - like growth factor I, seems to play a major role in the normal and tumoral development of the nervous system. Glioblastoma is the mostfrequent brain tumor in man and is usually fatal. Both human and rat gliomacells express high amounts of lGF-1. When rat glioma cells are transfected withvectors expressing either IGF-I antisense RNA or inducing IGF RNA - DNA triplehelix, the synthesis of IGF-1 was stopped on translation or transcription levels,respectively. Down-regulation in the expression of IGF-I coincides with the reappearance of B-7 and MHC class 1 antigens at the surface of transfected cells.When injected subcutaneously, the transfected cancer cells initiate an immunereaction involving CD8-F lymphocytes, followed by tumor regression. The«anti-gene» strategy for clinical therapy of glioblastoma, and other tumors expressing IGF-I such hepatomas were introduced in University Hospitals of Cleveland (USA), Shanghai (China), Krakow and Bydgoszcz (Poland).

Relation:

Biotechnologia, vol.61, 2 (2003)-.

Volume:

61

Issue:

2

Start page:

182

End page:

191

Detailed Resource Type:

Article

Format:

application/pdf

Resource Identifier:

0860-7796 ; oai:rcin.org.pl:135649 ; IChB B-57

Source:

Library of Institute of Bioorganic Chemistry PAS

Language:

eng

Language of abstract:

eng

Temporal coverage:

1988-2010

Rights:

Creative Commons Attribution BY-SA 4.0 license

Terms of use:

Copyright-protected material. [CC BY-SA 4.0] May be used within the scope specified in Creative Commons Attribution BY-SA 4.0 license, full text available at:

Digitizing institution:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Original in:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open