Subtitle:

Reverse transcriptase as the enzyme responsible for the genetic variability of human immunodeficiency virus (HIV)

Publisher:

Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS

Abstract:

Human immunodeficiency virus (HIV), the causative agent ofAIDS, belongsto the particularly dangerous and, as a result, the most extensively studied viruses. Until now no effective method protecting against this pathogen has beendeveloped. The major problem is the unusual genetic variability of HIV, whichhelps the virus to escape from immunological response and to produce drug-resistant mutants. Most of the collected data suggest that HIV-encoded reverseiransciiptase (HIV RT) is the main facto.- responsible for the continuos generation of new viral variants. There are two primary mechanisms involved in thegeneration of HIV mutants: high error prone replication and genetic RNA recombination. In this article both processes are discussed in detail.

Relation:

Biotechnologia, vol.56, 1 (2002)-.

Volume:

56

Issue:

1

Start page:

24

End page:

34

Detailed Resource Type:

Article

Format:

application/pdf

Resource Identifier:

0860-7796 ; oai:rcin.org.pl:138379 ; IChB B-52

Source:

Library of Institute of Bioorganic Chemistry PAS

Language:

pol

Language of abstract:

eng

Temporal coverage:

1988-2010

Rights:

Creative Commons Attribution BY-SA 4.0 license

Terms of use:

Copyright-protected material. [CC BY-SA 4.0] May be used within the scope specified in Creative Commons Attribution BY-SA 4.0 license, full text available at:

Digitizing institution:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Original in:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open