Over the last decade, antisense oligodeoxynucleotides and ribozymes haveemerged as valuable biochemical tools and promising therapeutic reagents inmedicine. This review describes the basic principles of their use in the strategyof directed RNA degradation. The rules for the rational choice of targeted RNAsequences, the properties of available RNA cleaving tools, as well as the majorproblems that limit the effectiveness of this new technology, are discussed. Selected examples of the successful use of antisense oligonucleotides and ribozymesas antiviral agents are presented.
Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.
Oct 2, 2020
Sep 10, 2020
|Strategia ukierunkowanej degradacji RNA oraz wybrane przykłady jej wykorzystania w terapii przeciwwirusowej||Oct 2, 2020|
Ziółkowski, Piotr Babula- Skowrońska, Danuta Kaczmarek, Małgorzata Cieśla, Agata Sadowski, Jan
Nowak, Jacek K.
Świątkowska, Agata Ciesiołka, Jerzy
Zimny, J. Czaplicki, A. Menke-Milczarek, I. Oleszczuk, S. Sowa, S.