Subtitle:

BSE - Identification and prophylactics

Publisher:

Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS

Abstract:

Prion diseases (for example: scrape of sheep, BSE, CJD of humans) areamong the most notable central nervous system degenerative disorders causedby the accumulation of modified cellular protein. The conversion of PrP(C) (thenormal cellular protein) into PrP(Sc) (the abnormal disease-causing isoform) involves a conformation change whereby the a-helical content diminishes and theamount of P sheet increases. PrP (Sc) is partially resistant to proteases, temperature, high and low pH. Because the incidence of prion diseases is due to severalfactors, various efforts need to be taken to reduce the scale and consequencesof the disease. They include post-mortem and in vivo diagnosis and prophylactics, i.e. monitoring of animals and feed control.

Relation:

Biotechnologia, vol.56, 1 (2002)-.

Volume:

56

Issue:

1

Start page:

136

End page:

141

Detailed Resource Type:

Article

Format:

application/pdf

Resource Identifier:

0860-7796 ; oai:rcin.org.pl:138406 ; IChB B-52

Source:

Library of Institute of Bioorganic Chemistry PAS

Language:

pol

Language of abstract:

eng

Temporal coverage:

1988-2010

Rights:

Creative Commons Attribution BY-SA 4.0 license

Terms of use:

Copyright-protected material. [CC BY-SA 4.0] May be used within the scope specified in Creative Commons Attribution BY-SA 4.0 license, full text available at:

Digitizing institution:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Original in:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open