The paper addresses to problems of carriers and antibodies in targetedtherapy. Also the new material ofliquid crystalline nature, designed for use as adrug vehicle in the immune targeting technique is presented and its property isdiscussed. Obtained by self-assembling, the ribbon-like supramolecular organisation products of some azo-dyes, particularly including Congo red and Evansblue, form micellar bodies of this carrier. They bind spontaneously and selectively to immune complexes but not to free antibodies. The binding strongly enhances the antigen - antibody interaction. Micelles ofthe carrier composed ofself-assembled molecules easily incorporate many foreign substances includingdrugs, favouring however those of possibly planar molecules. The excess of carrier leaves the organism rapidly through the urine tract, reducing the possibleside effects. The nature of chromonic liquid crystalline material is suitable formany modifications and adapting elaboration.
Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.
Oct 2, 2020
Sep 14, 2020
|Przeciwciała i nośniki leków w terapii celowanej - postęp i ograniczenia||Oct 2, 2020|
Ziółkowski, Piotr Babula- Skowrońska, Danuta Kaczmarek, Małgorzata Cieśla, Agata Sadowski, Jan
Nowak, Jacek K.
Szwaczkowski, Tomasz Świtoński, Marek