Tytuł:

Genetic mofification of secondary metabolic pathways

Inny tytuł:

Genetic mofification of secondary metabolic pathways

Twórca:

Wysokińska, Halina

Wydawca:

Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS

Data wydania/powstania:

2000

Temat i słowa kluczowe:

biotechnology

Abstrakt:

The examples given in this presentation show that the levels of secondarymetabolites can be modified by genetic engineering methods. In these methods, the specific genes encoding enzymes involved in key steps of biosyntheticpathway can be transferred and expressed in cell lines, hairy root cultures ortransgenic plants of the same or another species. Overexpression of the enzymes may lead to the accumulation of intermediates of pathways and increased synthesis of desirable products. Best results will be obtained when theoverproduced enzyme activity is clearly the rate-limiting step in the pathway.Therefore, better knowledge of the limiting steps of the pathways is required.The successful of biosynthetic pathways regulation may also be achieved byexpressing antisense RNA which is complementary to the mRNA encoding pathway enzyme or by genetic manipulation of degradative pathways. It should bementioned that genetic engineering also plays a role in the development ofnovel plant-derived drugs. As secondary metabolites are important in the defense of plants against pathogens, such engineered plants may show an increase inresistance against pathogens.

Czasopismo/Seria/cykl:

Biotechnologia, vol.51, 4 (2000)-.

Tom:

51

Zeszyt:

4

Strona pocz.:

48

Strona końc.:

61

Typ zasobu:

Text

Szczegółowy typ zasobu:

Article

Format:

application/pdf

Identyfikator zasobu:

0860-7796 ; IChB B-47

Źródło:

Library of Institute of Bioorganic Chemistry PAS

Język:

pol

Język streszczenia:

eng

Zakres czasowy:

1988-2010

Prawa:

Creative Commons Attribution BY-SA 4.0 license

Zasady wykorzystania:

Copyright-protected material. [CC BY-SA 4.0] May be used within the scope specified in Creative Commons Attribution BY-SA 4.0 license, full text available at:

Digitalizacja:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Lokalizacja oryginału:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Dofinansowane ze środków:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Dostęp:

Open