Perspectives for Medicinal Applications of Synthetic Oligonucleotides: Antisense Technology
Komitet Biotechnologii PAN ; Instytut Chemii Bioorganicznej PAN
Zeszyt specjalny. Polish - Japan Issue
Pharmaceutical industry is entering the era of “chirotechnology revolution”: in many countriesjany potential drug containing asymmetry centres has to be tested in its stereochemically pureforms. In the authors’ laboratory many efforts have been made, with a certain extent of success,to stereocontrolled chemical synthesis of oligonucleoside phosphorothioates and methanephosphonates. Stability of stereoregular oligonucleotides towards selected nucleases, as well as thethermal stability of duplexes formed with DNA and RNA were investigated. Other strategiesleading to antisense oligonucleotides try to avoid P-chirality by replacement of phosphates withachiral phosphorodithioates or moieties like formacetal, sulphones, diethylsilo.xanes etc.
Biotechnologia, vol.35, 4 (1996)-.
0860-7796 ; oai:rcin.org.pl:146558 ; IChB B-31
Biblioteka Instytutu Chemii Bioorganicznej PAN
Licencja Creative Commons Uznanie autorstwa-Na tych samych warunkach 4.0
Instytut Chemii Bioorganicznej Polskiej Akademii Nauk
Instytut Chemii Bioorganicznej Polskiej Akademii Nauk
9 lis 2020
9 lis 2020
50
https://rcin.org.pl/publication/182228
Edition name | Date |
---|---|
Perspectives for Medicinal Applications of Synthetic Oligonucleotides: Antisense Technology | 9 lis 2020 |
Borkowska, Bożenna
Ziółkowski, Piotr Babula- Skowrońska, Danuta Kaczmarek, Małgorzata Cieśla, Agata Sadowski, Jan
Boczkowska, Małgorzata Guga, Piotr