Subtitle:

Structure, expression and engineering of miik protein genes

Publisher:

Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS

Abstract:

Expression of milk protein genes is regulated by hormones, growth factors and extracellularmatrix. Prolactin, the major lactogenic hormone, promotes all stages of casein gene expression.Besides prolactin, also growth hormone may directly induce expression of milk protein genes.Computer analysis, mutation experiments and DNA-protein binding experiments enabled identification of mammary-specific transcription factors and cis-regulatoiy sequences in milk proteingene promoters. Also, transgene technology enables recognition of regulatory sequences in milkprotein genes. Moreover, transgenic animals carrying structural genes of human proteins fusedto mammary specific promoters are considered as living “bioreactors” designated to producehuman proteins for pharmaceutical use.

Relation:

Biotechnologia, vol.33, 2 (1996)-.

Volume:

33

Issue:

2

Start page:

81

End page:

94

Detailed Resource Type:

Article

Format:

application/pdf

Resource Identifier:

0860-7796 ; oai:rcin.org.pl:147104 ; IChB B-29

Source:

Library of Institute of Bioorganic Chemistry PAS

Language:

eng

Language of abstract:

eng

Temporal coverage:

1988-2010

Rights:

Creative Commons Attribution BY-SA 4.0 license

Terms of use:

Copyright-protected material. [CC BY-SA 4.0] May be used within the scope specified in Creative Commons Attribution BY-SA 4.0 license, full text available at:

Digitizing institution:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Original in:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open