Scientific adviser: Prof. Mariusz Jaskólski
This doctoral thesis presents studies of pathogenesis related proteins of class 10 (PR-10). Sofar no specific function has been assign to this group. The PR-10 family consist of small,intracellular biomolecules of acidic character, whose expression is elevated in response to bioticand abiotic stress. The characteristic fold of PR-10 proteins, which consists of seven antiparallelβ strands wrapped around an extended, C-terminal α helix, creates a globular protein with alarge, hydrophobic cavity, which is capable of accommodating small-molecule ligands. Althoughmany constitutively expressed plant proteins exhibit the PR-10 fold, they are not typicallyrelated to pathogenesis. A variety of different ligand classes, including cytokinins, flavonoids andsteroids, have been demonstrated so far (via crystallographic and biophysical methods) tooccupy the PR-10 cavity.
Creative Commons Attribution BY-SA 4.0 license
Institute of Bioorganic Chemistry of the Polish Academy of Science
Institute of Bioorganic Chemistry of the Polish Academy of Science
Sep 8, 2021
Sep 8, 2021
85
https://rcin.org.pl/publication/245705
Edition name | Date |
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Complexes of PR-10 proteins with plant hormones: crystallographic and biophysical studies | Sep 8, 2021 |