Institutional creator:

Department of Experimental and Clinical Neuropathology MMRI

Contributor:

Mossakowski, M.J dr

Place of publishing:

Warsaw

Description:

Clinical, anatomical and histological diagnosis

Abstract:

Histological diagnosis: Encephalopatia portosystemica.Autopsy examination of 69-year-old patient was performed. Neuropathological evaluation in light microscopy was based on brain paraffin sections stained with Hematoxylin-eosin and Heidenhain method.Profound pathological changes were found in the cerebral cortex, consisting of diffuse loss of nerve cells, mainly in its deeper layers. These defects were most prominent in frontal and central cortex /central frontal ganglia/. In the central cortex, the cellular depletions were accompanied by the formation of small cavities, which merged together and gave an image of a spongy state. The cellular defects were not accompanied by glial reaction. The nerve fibers in the vicinity of the cavities had normal myelin sheaths. Numerous small reaction-free cavities were also seen in the striatum and globus pallidus. Some of these lay adjacent to vessels, and some had a look-alike appearance in the central cortex. Nerve cell steatosis was significant in some areas. The vessels showed slight fibrosis of the walls.

Format:

pdf

Resource Identifier:

oai:rcin.org.pl:209448

Language:

pol

Language of abstract:

eng

Rights:

Creative Commons Attribution BY 4.0 license

Terms of use:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitizing institution:

Mossakowski Medical Research Institute PAS

Original in:

Library of the Mossakowski Medical Research Institute PAS

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open