Institutional creator:

Department of Experimental and Clinical Neuropathology MMRI

Contributor:

E.Osetowska, dr hab.

Place of publishing:

Warsaw

Description:

Clinical, anatomical and histological diagnosis

Abstract:

Histological diagnosis: Glioblastoma multiforme pontis ad cerebellum progrediens. Haemorrhagia secundaria.Autopsy examination of 7-year-old patient was performed. Neuropathological evaluation in light microscopy was based on brain paraffin sections stained with Hematoxylin-eosin. The tumor tissue was very rich, there was marked cellular polymorphism, and numerous circular and diffuse hemorrhagic foci were seen. Among the small, round and spindle-shaped cells, large, bright cells with rich chromatin stroma, similar to hyperplastic astrocytes, were observed; large, bright pink multinucleated cells with hyperchromatic nuclei arranged at the periphery; numerous, monstrous mitoses; clumped nuclear conglomerates without visible protoplasmic surround; small round richly chromatin cells without visible protoplasm were observed. The tumor stroma was formed by very numerous vessels, often with vitreous changes in the walls. Very numerous hemorrhages were seen both in the central part of the tumor and in the surrounding area. Tumor cells were widely spread, without any visible border in the surroundings: hyperplastic activated astrocytes were found distant in the cancer-free tissue, both in the pons and cerebellum. The granular layer of the cerebellum was severely thinned; Purkinje cells underwent segmental atrophy. Brainstem neurons were compressed by edema, with shrunken nuclei and hemolyzed protoplasm. The lesion pattern was indicative of very high tumor malignancy.

Format:

pdf

Resource Identifier:

oai:rcin.org.pl:213844

Language:

pol

Language of abstract:

eng

Rights:

Creative Commons Attribution BY 4.0 license

Terms of use:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitizing institution:

Mossakowski Medical Research Institute PAS

Original in:

Library of the Mossakowski Medical Research Institute PAS

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open