Institutional creator:

Mossakowski Medical Research Institute Polish Academy of Sciences

Contributor:

Walerych, Dawid (Promoter)

Place of publishing:

Warsaw

Description:

Bibliografia zawiera 312 pozycji ; 152 s.: il., wykr., tabl. ; 30 cm.

Degree name:

doctor

Level of degree:

2

Degree discipline :

medical sciences

Degree grantor:

Mossakowski Medical Research Institute Polish Academy of Sciences

Abstract:

For effective cancer treatment strategies it is crucial to identify the role of driver oncogenes, which are frequently activated in neoplasia and play a pivotal role in driving cancer development and progression. The research within this doctoral dissertation was aimed to elucidate the molecular programs associated with key oncogenes, including the proteasome, mutant TP53, MYC, mutant KRAS, lncRNAs, and their roles in driving cancer progression. The study included diverse cancer types: colon, lung, pancreatic, head and neck, and multiple myeloma. These cancer types were chosen based on the presence of activated oncogenes and the high number of deaths they are predicted to cause in the upcoming decade in the US and EU countries, including Poland. Through an integrative approach combining transcriptomics and proteomics analysis, this project aimed to obtain a comprehensive understanding of the molecular landscape underlying the activity of driver oncogenes in the selected neoplasias. This study also aimed to identify potential therapeutic targets for improved treatment regimens by leveraging the power of omics data and integrative analysis.

Detailed Resource Type:

PhD Dissertations

Resource Identifier:

oai:rcin.org.pl:246959

Source:

IMDiK PAN, call.ZS 442 ; click here to follow the link

Language:

eng

Language of abstract:

eng

Rights:

Creative Commons Attribution BY 4.0 license

Terms of use:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitizing institution:

Mossakowski Medical Research Institute PAS

Original in:

Library of the Mossakowski Medical Research Institute PAS

Access:

Open