Tytuł:

Influence of short-term ischemia on the ultrastructure of hippocampal gyrus in Mongolian gerbil. III. Synapses in late stage of the pathological process

Twórca:

Gajkowska, Barbara ; Gadamski, Roman (1933–2015) ; Mossakowski, Mirosław Jan (1929–2001)

Wydawca:

Zakład im. Ossolińskich - Wydawnictwo Polskiej Akademii Nauk

Miejsce wydania:

Wrocław ; Warszawa ; Kraków

Data wydania/powstania:

1992

Typ obiektu:

Journal/Article

Temat i słowa kluczowe:

Brain ischemia ; hippocampus ; CA1 sector of Ammon's horn ; synapses

Abstrakt:

Electron microscope analysis of the CA, Ammon’s horn sector was performed in Mongolian gerbils three days after an incident of short-term ischemia of the forebrain. CAt pyramidal neurons showed advanced disintegration. Some GABA-er- gic interneurons revealed ultrastructural alteration of variable degree. The latter finding contradicts the generally helt view on the relative resistance of CAt sector interneurons to the ischemic injury. Synapses localized in all cortical layers of the CAj sector exhibited ultrastructural abnormalities involving both pre-and postsynap- tic parts. They consisted in marked swelling and accumulation of unbound electron dense material, considered as calcium deposits. Presynaptic parts revealed additionally reduced number of synaptic vesicles and their abnormal distribution. Contrary to the early postischemic period, the most severe synaptic alterations appeared in stratum pyramidale, radiatum and oriens, involving both small dendritic branchings and their spines as well as large shafts of both basal and apical pyramidal dendrites. Synaptic alterations especially features of the postsynaptic damage correspond to those indicating excitotoxic neuronal lesions. Presynaptic alterations may indicate both cessation of neurotransmission function as well as direct ischemic damage. The presence of calcium deposition seems to favour the former possibility.

Czasopismo/Seria/cykl:

Neuropatologia Polska

Tom:

30

Zeszyt:

1

Strona pocz.:

13

Strona końc.:

28

Typ zasobu:

Text

Szczegółowy typ zasobu:

Article

Format:

application/pdf

Język:

eng

Prawa:

Creative Commons Attribution BY 4.0 license

Zasady wykorzystania:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitalizacja:

Mossakowski Medical Research Institute PAS

Lokalizacja oryginału:

Library of the Mossakowski Medical Research Institute PAS

Dofinansowane ze środków:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Dostęp:

Open