Tytuł:

CHANGES IN THE ACTIVITY OF ALKALINE PHOSPHATASE AND ADENYLATE CYCLASE IN THE BRAIN VASCULAR NETWORK IN EXPERIMENTAL POSTRESUSCITATION SYNDROME

Twórca:

Szumańska, G. ; Mossakowski, Mirosław Jan (1929–2001) ; Januszewski, Sławomir

Wydawca:

Zakład im. Ossolińskich - Wydawnictwo Polskiej Akademii Nauk

Miejsce wydania:

Wrocław ; Warszawa ; Kraków

Data wydania/powstania:

1988

Typ obiektu:

Journal/Article

Temat i słowa kluczowe:

alkaline phosphatase ; adenyl cyclase activity ; brain ; post-resuscitation syndrom

Abstrakt:

Activity of alkaline phosphatase and adenylate cyclase was evaluated in the brain vascularnetwork of rats subjected to 10 min clinical death due to cardiac arrest.Progressive decrease of both enzymes activities was noted in the early survival stages, reachingthe lowest intensity in 24th h after ischemic incident. Restitution of enzymatic activity was observed2 days later, although even then it did not reach intensity typical for normal controls. Electronmicroscopic study revealed disturbances of normal polarity of enzyme distribution in thecytoplasmic membranes of vascular endothelia. Activity of enzymes disappeared from luminalendothelial surfaces, appearing on abluminal ones and in the capillary basal membranes.Ultrastructural picture of the cerebral capillaris was additionally characterized by remarkableincrease of micropinocytic vesicles, and appearance of coated vesicles as well as canalicularstructures. Swelling of endothelial cytoplasm and widening of interendothelial clefts were alsopresent.The results obtained indicate that deep 10 min ischemia in experimentally induced clinicaldeath is leading to the impairment of transport functions in damaged cerebral capillaryvessels.

Czasopismo/Seria/cykl:

Neuropatologia Polska

Tom:

26

Zeszyt:

3

Strona pocz.:

335

Strona końc.:

357

Typ zasobu:

Text

Szczegółowy typ zasobu:

Article

Format:

pdf

Język:

pol

Język streszczenia:

eng ; rus

Prawa:

Creative Commons Attribution BY 4.0 license

Zasady wykorzystania:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitalizacja:

Mossakowski Medical Research Institute PAS

Lokalizacja oryginału:

Library of the Mossakowski Medical Research Institute PAS

Dofinansowane ze środków:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Dostęp:

Open