Title:

Effect of a calcium channel blocker on the development of ischemic neuron damage in sector CA1 of the horn of Ammon in Mongolian gerbils

Creator:

Mossakowski, Mirosław Jan (1929–2001) ; Gadamski, Roman (1933–2015)

Publisher:

Zakład im. Ossolińskich - Wydawnictwo Polskiej Akademii Nauk

Place of publishing:

Wrocław ; Warszawa ; Kraków

Date issued/created:

1987

Type of object:

Journal/Article

Subject and Keywords:

Calcium ; Ischemic neuron damage ; CA1 ; Ammon's horn

Abstract:

The protective effect of Nimotop (Bayer) — a calcium channel blocker, beingan equivalent of nimodipine, on the development of selective damage of CAi neuronsof Ammon’s horn resulting from short-term ischemia of forebrain in Mongoliangerbils was evaluated. The experimental animals, subjected to 7.5 min bilateralligation of common carotid arteries were given the drug in a dosis of 1 mg/kgbody weight in the form of intraperitoneal injection at various periods in relationto cerebral ischemia. In group 1 — Nimotop was administered twice — 60 mjnbefore ischemia and 5 h after arterial release. In group 2 a double dosis of thedrug was given 15 min prior to carotid occlusion and in 3rd hour of the recirculation.In group 3 the scheme applied in group 2 was supplemented with a thirddosis of Nimotop given 24 h following cerebral ischemia. The latter was the timeof a single drug dosis application in group 4. The control animals were subjectedto cerebral ischemia with no medication.

Relation:

Neuropatologia Polska

Volume:

25

Issue:

4

Start page:

439

End page:

450

Resource type:

Text

Detailed Resource Type:

Article

Format:

pdf

Language:

pol

Language of abstract:

eng ; rus

Rights:

Creative Commons Attribution BY 4.0 license

Terms of use:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitizing institution:

Mossakowski Medical Research Institute PAS

Original in:

Library of the Mossakowski Medical Research Institute PAS

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open

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