Title:

Pathophysiological and Morphological Observation after 30 minBilateral Occlusion of the Common Carotid Artery in Gerbils

Creator:

Kapuściński, Andrzej (1937–2018)

Contributor:

Mossakowski, Mirosław Jan (1929–2001)

Publisher:

Pergamon Press

Place of publishing:

Oxford; New York

Date issued/created:

1982

Description:

63-82 pp, il.11

Type of object:

Book/Chapter

Subject and Keywords:

Mongolian gerbil ; Cerebral ischemia ; Bilateral carotid occlusion ; Pathophysiological alterations

Abstract:

The 30 min cerebral ischemia was induced by bilateral occlusion of the common carotid artery in Mongolian gerbils under intra-peritoneal pentobarbital anesthesia. The short duration unila-teral carotid occlusion proceded the main ischemic insult to check anomalies of the Willis circle. Cortical bioelectric ac-tivity, arterial blood pressure, respiratory and cardiac fun-ction were continuously recorded during the ischemic period and recovery up to 9 hrs. Postmortem intra-cardiac dye infusion was performed to demonstrate communications between the vertebro-basilar and carotid circulations. In the other group, animals were sacrificed every hour after ischemia and prepared for the light microscopic observations. During ischemia blood pressure increased and electrocerebral silence as recorded. Release of the carotid arteries produced drop of blood pressure below the control values. Recovery of cerebral bioelectric activity took place between 50 min and 3 hrs after ischemia reaching in some cases the control recording. Afterwards the slow decline of electrocerebral activity appeared. The morphological altera-tions were observed already 1 h after ischemia. During recovery of cerebral bioelectric activity with tendency toward normali-zation, considerable progression of structural alterations exi-sted with dominance of cytotoxic edema. They suppressed the ce-rebral function leading to the brain death..

References:

biblliograf..

Relation:

Advances in the Biosciences Vol.43 Stroke: Animals Models

Resource type:

Text

Detailed Resource Type:

Chapter

Resource Identifier:

pdf

Language:

eng

Rights:

Creative Commons Attribution BY 4.0 license

Terms of use:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitizing institution:

Mossakowski Medical Research Institute PAS

Original in:

Library of the Mossakowski Medical Research Institute PAS

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open