Contributor:

Mossakowski, Mirosław Jan (1929–2001)

Publisher:

Pergamon Press

Place of publishing:

Oxford; New York

Description:

63-82 pp, il.11

Type of object:

Książka/Rozdział

Abstract:

The 30 min cerebral ischemia was induced by bilateral occlusion of the common carotid artery in Mongolian gerbils under intra-peritoneal pentobarbital anesthesia. The short duration unila-teral carotid occlusion proceded the main ischemic insult to check anomalies of the Willis circle. Cortical bioelectric ac-tivity, arterial blood pressure, respiratory and cardiac fun-ction were continuously recorded during the ischemic period and recovery up to 9 hrs. Postmortem intra-cardiac dye infusion was performed to demonstrate communications between the vertebro-basilar and carotid circulations. In the other group, animals were sacrificed every hour after ischemia and prepared for the light microscopic observations. During ischemia blood pressure increased and electrocerebral silence as recorded. Release of the carotid arteries produced drop of blood pressure below the control values. Recovery of cerebral bioelectric activity took place between 50 min and 3 hrs after ischemia reaching in some cases the control recording. Afterwards the slow decline of electrocerebral activity appeared. The morphological altera-tions were observed already 1 h after ischemia. During recovery of cerebral bioelectric activity with tendency toward normali-zation, considerable progression of structural alterations exi-sted with dominance of cytotoxic edema. They suppressed the ce-rebral function leading to the brain death..

References:

biblliograf..

Relation:

Advances in the Biosciences Vol.43 Stroke: Animals Models

Detailed Resource Type:

Rozdział

Resource Identifier:

oai:rcin.org.pl:69576 ; pdf

Language:

eng

Rights:

Licencja Creative Commons Uznanie autorstwa-Na tych samych warunkach 4.0

Terms of use:

Zasób chroniony prawem autorskim. [CC BY 4.0 Międzynarodowe] Korzystanie dozwolone zgodnie z licencją Creative Commons Uznanie autorstwa 4.0, której pełne postanowienia dostępne są pod adresem: ; -

Digitizing institution:

Instytut Medycyny Doświadczalnej i Klinicznej im. M. Mossakowskiego Polskiej Akademii Nauk

Original in:

Biblioteka Instytutu Medycyny Doświadczalnej i Klinicznej im. M. Mossakowskiego PAN

Projects co-financed by:

Program Operacyjny Polska Cyfrowa, lata 2014-2020, Działanie 2.3 : Cyfrowa dostępność i użyteczność sektora publicznego; środki z Europejskiego Funduszu Rozwoju Regionalnego oraz współfinansowania krajowego z budżetu państwa

Access:

Otwarty