Tytuł:

The use of RNA molecules in modeling of gene expression

Inny tytuł:

The use of RNA molecules in modeling of gene expression

Twórca:

Pieczyński, Marcin ; Bielewicz, Dawid ; Dolata, Jakub ; Szweykowska-Kulińska, Zofia

Wydawca:

Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS

Data wydania/powstania:

2010

Temat i słowa kluczowe:

biotechnologia

Abstrakt:

Gene silencing and modeling of gene expression are classical approaches in studying gene functions. There are many methods available which use RNA molecules as gene silencing inducers or gene expression modulators. RNA molecules act at different levels of gene expression: chromatin structure, gene transcription and pre-mRNA maturation. In the last decade, new methods for silencing and modeling of gene expression emerged, utilizing RNAi phenomenon, trans-splicing, RNA directed DNA metylation, ribozymes, artificial microRNAs, ryboswitches, and U1 interference. In this paper, we review some of the methods which were successfully used for gene function studies and as therapeutic tools against different plant and human diseases.

Czasopismo/Seria/cykl:

Biotechnologia, vol.90, 3 (2010)-.

Tom:

90

Zeszyt:

3

Strona pocz.:

7

Strona końc.:

28

Typ zasobu:

Text

Szczegółowy typ zasobu:

Article

Format:

application/pdf

Identyfikator zasobu:

IChB B-85

Źródło:

Biblioteka Instytutu Chemii Bioorganicznej PAN

Język:

pol

Język streszczenia:

eng

Zakres czasowy:

2010

Prawa:

Creative Commons Attribution BY-SA 4.0 license

Zasady wykorzystania:

Copyright-protected material. [CC BY-SA 4.0] May be used within the scope specified in Creative Commons Attribution BY-SA 4.0 license, full text available at:

Digitalizacja:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Lokalizacja oryginału:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Dofinansowane ze środków:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Dostęp:

Open