Subtitle:

The structure and properties of Human papillomavirus

Publisher:

Komitet Biotechnologii PAN ; Instytut Chemii Bioorganicznej PAN

Description:

prace przeglądowe

Abstract:

Human papillomaviruses (HPVs) are a large group, with over 100 genotypes, of small nonenveloped, double-stranded DNA viruses. HPV types may be classified by infection location on the body each virus tends to infect and its potential for oncogenesis. ‘High-risk’ and ‘low-risk’ nomenclature was proposed for HPV genotypes (HPV-HR and HPV-LR). HPV is the major etiologie factor in cervical cancer and is found in the majority of cervical tumors. The major mechanisms through which HPV contributes to neoplastic initiation and progression include the activity of two viral oncoprotein, E6 and E7, which interfere with critical cell cycle tumor suppressive proteins, p53 and pRB. However, HPV infection is not a sufficient cause of cervical cancer and other cofactors contribute to the multi-step process or tumor formation, such as individual genetic variation as well as environmental factors. Recently, prophylactic HPV vaccines have been shown to be effective in preventing infection in young women.

Relation:

Biotechnologia, vol.90, 3 (2010)-.

Volume:

90

Issue:

3

Start page:

126

End page:

145

Detailed Resource Type:

Artykuł

Format:

application/pdf

Resource Identifier:

oai:rcin.org.pl:71500 ; IChB B-85

Source:

Biblioteka Instytutu Chemii Bioorganicznej PAN

Language:

pol

Language of abstract:

eng

Temporal coverage:

2010

Rights:

Licencja Creative Commons Uznanie autorstwa-Na tych samych warunkach 4.0

Terms of use:

-

Digitizing institution:

Instytut Chemii Bioorganiczneji Polskiej Akademii Nauk

Original in:

Instytut Chemii Bioorganiczneji Polskiej Akademii Nauk

Projects co-financed by:

Program Operacyjny Polska Cyfrowa, lata 2014-2020, Działanie 2.3 : Cyfrowa dostępność i użyteczność sektora publicznego; środki z Europejskiego Funduszu Rozwoju Regionalnego oraz współfinansowania krajowego z budżetu państwa

Access:

Otwarty