RCIN and OZwRCIN projects

Object

Title: Przekaźnictwo sygnału wapniowego w zrekonstruowanych oocytach i klonalnych zarodkach ssaków w warunkach sztucznej aktywacji

Creator:

Samiec, Marcin

Date issued/created:

2010

Resource type:

Tekst

Subtitle:

Calcium signal transduction in reconstructed oocytes and somatic cell nuclear transfer embryos of mammals in the conditions of artificial activation

Publisher:

Komitet Biotechnologii PAN ; Instytut Chemii Bioorganicznej PAN

Description:

prace przeglądowe

Abstract:

One of the most important factors that affect the developmental competences of mammalian somatic cell nuclear transfer (SCNT) embryos is artificial activation of reconstructed oocytes (clonal cybrids). However, calcium signal transduction in a cytosol of such oocytes that has been initiated incorrectly by physical or chemical activating factors (electric pulses or specific ionophore antibiotics) can stimulate not only the development of cloned embryos. It can also induce apoptotic cell death following considerable elevation in intracellular calcium concentration and thereby excitotoxicity of Ca^+ ions. Therefore, the basic objective of this paper is to present the current knowledge on the mechanisms regulating biochemical and biophysical proapoptotic changes within SCNT embryo which were triggered by the process of excitotoxic calcium signal transmission resulting from an improper artificial activation of clonal cybrid.

Relation:

Biotechnologia, vol.88, 1 (2010)-.

Volume:

88

Issue:

1

Start page:

46

End page:

65

Detailed Resource Type:

Artykuł

Format:

application/pdf

Resource Identifier:

0860-7796 ; oai:rcin.org.pl:71736 ; IChB B-83

Source:

Biblioteka Instytutu Chemii Bioorganicznej PAN

Language:

pol

Language of abstract:

eng

Temporal coverage:

2010

Rights:

Licencja Creative Commons Uznanie autorstwa-Na tych samych warunkach 4.0

Terms of use:

-

Digitizing institution:

Instytut Chemii Bioorganiczneji Polskiej Akademii Nauk

Original in:

Instytut Chemii Bioorganiczneji Polskiej Akademii Nauk

Projects co-financed by:

Program Operacyjny Polska Cyfrowa, lata 2014-2020, Działanie 2.3 : Cyfrowa dostępność i użyteczność sektora publicznego; środki z Europejskiego Funduszu Rozwoju Regionalnego oraz współfinansowania krajowego z budżetu państwa

Access:

Otwarty

Object collections:

Last modified:

Oct 2, 2020

In our library since:

May 28, 2019

Number of object content downloads / hits:

537

All available object's versions:

https://rcin.org.pl/publication/94052

Show description in RDF format:

RDF

Show description in RDFa format:

RDFa

Show description in OAI-PMH format:

OAI-PMH

×

Citation

Citation style:

This page uses 'cookies'. More information