Title:

Xanthohumol and other prenylated flavonoids of hop cones - biological and technological aspects

Subtitle:

Xanthohumol and other prenylated flavonoids of hop cones - biological and technological aspects

Creator:

Gołąbczak, Jadwiga ; Gendaszewska-Darmach, Edyta

Publisher:

Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS

Date issued/created:

2010

Description:

prace przeglądowe

Subject and Keywords:

biotechnology

Abstract:

Hops, the female inflorescences of the hop plant (Humulus lupulus) are used in the brewing industry to add bitterness and aroma to beer. This raw material is a rich source of terpenoid essential oils and terpenophenolic resins (bitter acids, prenylated flavonoids). Xanthohumol is the most abundant (80-90“b) of total amount of prenylated flavonoids in hop cones (up to ]% w/w). Xanthohumol has received much attention in recent years as a cancer chemopreventive agent because of its ability to inhibit initiation, promotion and progression stages of carcinogenesis. It’s beneficial effects on health also include antibacterial, antioxidant, and antiinflamattory properties. Hydrophobic xanthohumol cannot be extracted with carbon dioxide under condition used for common hop extract destined for the application in the brew house (300 bar, 50°C). This flavonoid remains in the waste product of the hops (spent hops) processing industry. Diverse extraction methods of spent hops by ethanol and supercritical CO2 at different pressures lead to the residues that contain more than 30% xanthohumol. The multistep process extraction and separation of xanthohumol from natural source (raw or waste hops) with organic solvent have been also conducted. Recently, a synthetic route to xanthohumol has also been described. The purpose of this review is to provide an overview of the chemistry, biosynthesis, biological activities, and biotechnological aspects of xanthohumol.

Relation:

Biotechnologia, vol.88, 1 (2010)-.

Volume:

88

Issue:

1

Start page:

82

End page:

96

Resource type:

Text

Detailed Resource Type:

Article

Format:

application/pdf

Resource Identifier:

0860-7796 ; IChB B-83

Source:

Library of Institute of Bioorganic Chemistry PAS

Language:

pol

Language of abstract:

eng

Temporal coverage:

2010

Rights:

Creative Commons Attribution BY-SA 4.0 license

Terms of use:

Copyright-protected material. [CC BY-SA 4.0] May be used within the scope specified in Creative Commons Attribution BY-SA 4.0 license, full text available at:

Digitizing institution:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Original in:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open