Object

Title: Comparative morphometric analysis of terminal vascularization of hippocampal CAI and CA3 sectors in Mongolian gerbils.

Subtitle:

Porównawcza analiza morfometryczna unaczynienia terminalnego okoiic CA1 i CA3 rogu Amona u chomików mongoiskich

Publisher:

Medical Publishing House

Place of publishing:

Warsaw

Abstract:

Comparative morphometric analysis of terminal vascularization (vessels with a diameter lower than 12.5 /ли) in theischemia-sensitive sector CAI and the ischemia-resistant sector CA3 of Ammon's horn in Mongolian gerbils was performed. Basing on numerous computer-counted parameters characterizing the terminal vascular network in bothhippocampal sectors and its relationship to the surrounding tissue, it was shown that a number of capillary vessels, theiraverage diameter, and exchange and flow surfaces were to a statistically significant degree lower in the pyramidal layer ofthe CAI sector as compared with those in CA3 sector. The number of pyramidal neurons in the pyramidal layer, counted per surface unit was in sector CAI higher than in sector CA3. The obtained data indicate clearly anangioarchitectonically dependent lower microvascular capacity of sector CA 1. However, these differences do not indicateper ле a leading role of the vascular factor in the pathomechanism of selective vulnerability to ischemia. They may be a factor facilitating neuronal damage evoked by the excitotoxic action of glutamate, observed in CAI sector as a result of forebrain ischemia.

Relation:

Folia Neuropathologica

Volume:

32

Issue:

1

Start page:

1

End page:

7

Detailed Resource Type:

Article

Format:

pdf

Resource Identifier:

oai:rcin.org.pl:71850

Language:

eng

Language of abstract:

eng ; pol

Rights:

Creative Commons Attribution BY 4.0 license

Terms of use:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitizing institution:

Mossakowski Medical Research Center PAS

Original in:

Library of the Mossakowski Medical Research Center PAS

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

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