@misc{Stec_Wojciech_J._Perspectives_1996,
 author={Stec, Wojciech J. and Guga, Piotr},
 volume={35},
 number={4},
 copyright={Creative Commons Attribution BY-SA 4.0 license},
 journal={Biotechnologia, vol.35, 4 (1996)-.},
 howpublished={online},
 year={1996},
 publisher={Committee on Biotechnology PAS},
 publisher={Institute of Bioorganic Chemistry PAS},
 language={eng},
 abstract={Pharmaceutical industry is entering the era of “chirotechnology revolution”: in many countriesjany potential drug containing asymmetry centres has to be tested in its stereochemically pureforms. In the authors’ laboratory many efforts have been made, with a certain extent of success,to stereocontrolled chemical synthesis of oligonucleoside phosphorothioates and methanephosphonates. Stability of stereoregular oligonucleotides towards selected nucleases, as well as thethermal stability of duplexes formed with DNA and RNA were investigated. Other strategiesleading to antisense oligonucleotides try to avoid P-chirality by replacement of phosphates withachiral phosphorodithioates or moieties like formacetal, sulphones, diethylsilo.xanes etc.},
 title={Perspectives for Medicinal Applications of Synthetic Oligonucleotides: Antisense Technology},
 type={Text},
 URL={http://rcin.org.pl/ichb/Content/146558/PDF/POZN271_182228_biotechnologia-1996-no4-stec.pdf},
 keywords={biotechnology},
}