From neoplastic neural development to gene therapy of brain tumors -IGF-I antisense and triple helix approaches

Trojan, Jerzy

doi:0860-7796

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From neoplastic neural development to gene therapy of brain tumors -IGF-I antisense and triple helix approaches Trojan, Jerzy

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From neoplastic neural development to gene therapy of brain tumors -IGF-I antisense and triple helix approaches

Trojan, Jerzy

Komitet Biotechnologii PAN ; Instytut Chemii Bioorganicznej PAN

2003

biotechnologia

IGF-I, insulin - like growth factor I, seems to play a major role in the normal and tumoral development of the nervous system. Glioblastoma is the mostfrequent brain tumor in man and is usually fatal. Both human and rat gliomacells express high amounts of lGF-1. When rat glioma cells are transfected withvectors expressing either IGF-I antisense RNA or inducing IGF RNA - DNA triplehelix, the synthesis of IGF-1 was stopped on translation or transcription levels,respectively. Down-regulation in the expression of IGF-I coincides with the reappearance of B-7 and MHC class 1 antigens at the surface of transfected cells.When injected subcutaneously, the transfected cancer cells initiate an immunereaction involving CD8-F lymphocytes, followed by tumor regression. The«anti-gene» strategy for clinical therapy of glioblastoma, and other tumors expressing IGF-I such hepatomas were introduced in University Hospitals of Cleveland (USA), Shanghai (China), Krakow and Bydgoszcz (Poland).

Biotechnologia, vol.61, 2 (2003)-.

0860-7796 ; IChB B-57

Biblioteka Instytutu Chemii Bioorganicznej PAN

eng

1988-2010

Licencja Creative Commons Uznanie autorstwa-Na tych samych warunkach 4.0

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk