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Modyfikacje genetyczne dróg wtórnego metabolizmu w roślinnych kulturach in vitro
Subtitle:Genetic mofification of secondary metabolic pathways
Creator: Publisher:Komitet Biotechnologii PAN ; Instytut Chemii Bioorganicznej PAN
Date issued/created: Subject and Keywords: Abstract:The examples given in this presentation show that the levels of secondarymetabolites can be modified by genetic engineering methods. In these methods, the specific genes encoding enzymes involved in key steps of biosyntheticpathway can be transferred and expressed in cell lines, hairy root cultures ortransgenic plants of the same or another species. Overexpression of the enzymes may lead to the accumulation of intermediates of pathways and increased synthesis of desirable products. Best results will be obtained when theoverproduced enzyme activity is clearly the rate-limiting step in the pathway.Therefore, better knowledge of the limiting steps of the pathways is required.The successful of biosynthetic pathways regulation may also be achieved byexpressing antisense RNA which is complementary to the mRNA encoding pathway enzyme or by genetic manipulation of degradative pathways. It should bementioned that genetic engineering also plays a role in the development ofnovel plant-derived drugs. As secondary metabolites are important in the defense of plants against pathogens, such engineered plants may show an increase inresistance against pathogens.
Relation:Biotechnologia, vol.51, 4 (2000)-.
Volume: Issue: Start page: End page: Resource type: Detailed Resource Type: Format: Resource Identifier: Source:Biblioteka Instytutu Chemii Bioorganicznej PAN
Language: Language of abstract: Temporal coverage: Rights:Licencja Creative Commons Uznanie autorstwa-Na tych samych warunkach 4.0
Terms of use: Digitizing institution:Instytut Chemii Bioorganicznej Polskiej Akademii Nauk
Original in:Instytut Chemii Bioorganicznej Polskiej Akademii Nauk
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