Title:

Struktura drugorzędowa i próba regulacji alternatywnego składania pre- mRNA genu MAPT

Creator:

Lisowiec, Jolanta

Date issued/created:

2014

Description:

Promotor pracy: Prof. dr hab. Ryszard Kierzek. Pracę wykonanow Instytucie Chemii BioorganicznejPolskiej Akademii Nauk w Poznaniuw Zakładzie Chemii i Biologii Strukturalnej Kwasów Nukleinowych

Location:

Poznań

Abstract:

Tau protein is a product of MAPT gene and belongs to the microtubule associatedprotein family. In 1998 the first mutation in MAPT gene was found, and over 40 mutationsare uncovered nowadays. MAPT gene mutations can be divided into two types. The first typecauses the change in biochemical properties of tau protein. The second one disruptsalternative splicing of exon 10. Alternative splicing of exon 10 produces 3R (without exon 10)and 4R (with exon 10) protein isoforms. In healthy brain the ratio of 3R and 4R forms isapproximately 1.

Start page:

1

End page:

164

Resource type:

Text

Detailed Resource Type:

PhD Dissertations

Format:

application/pdf

Language:

pol

Language of abstract:

eng

Rights:

Creative Commons Attribution BY-SA 4.0 license

Terms of use:

-

Digitizing institution:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Original in:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open