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Dicer ribonucleases play an important role in the biogenesis of small regulatory RNAs by cleaving singlestranded precursors adopting stem-loop structures (pre-miRNAs) as well as double-stranded RNAs (dsRNAs)into short RNA duplexes containing functional microRNAs (miRNAs) or small interfering RNAs (siRNAs),respectively. miRNA or siRNA together with Argonaute (Ago) proteins form RNA-induced silencing complexwhich mediates post-transcriptional gene silencing. However, there is a growing number of reports describingDicer’s functions that are not related to its ribonuclease activity, and the biogenesis of small regulatory RNAs.
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Terms of use: Digitizing institution:Instytut Chemii Bioorganicznej Polskiej Akademii Nauk
Original in:Instytut Chemii Bioorganicznej Polskiej Akademii Nauk
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