Mossakowski Medical Research Center Polish Academy of Sciences. Department of Neuromuscular
Muscle segment examination in light & electron microscopy
Diagnosis: Suspected late glycogen II. In the collected specimen, muscle fibers of different diameters mixed irregularly between them are separated by connective tissue within peri and endomysium. The division of fibers into metabolic types retained type 1 fibers clearly smaller. Individual fibers show signs of necrosis with phagocytosis, perivascular single clusters of lymphoid cells are also visible. Morphological image of the slice requires further ultrastructural assessment. In the ultrastructural analysis, the abnormal mitochondrial structure was visualized within type 1 fibers, characterized by swelling, crest loss with complete emptying of the mitochondrial interior. Conclusions: the observed changes may suggest a defect of mitochondrial enzymes.
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Mossakowski Medical Research Institute PAS
Library of the Mossakowski Medical Research Institute PAS
Feb 1, 2022
Apr 16, 2020
33
https://rcin.org.pl/imdik/publication/111699
Edition name | Date |
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opis nr 21/14 | Feb 1, 2022 |