File of histopathological evaluation of nervous system diseases (1965) - nr 106/65

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Title: File of histopathological evaluation of nervous system diseases (1965) - nr 106/65

Abstract:

Histological diagnosis: Encephalomalacia recens et inveterata. Thrombosis a. cerebri mediae sin. Autopsy examination of 59-year-old patient was performed. Neuropathological evaluation in light microscopy was based on brain paraffin sections stained with with Hematoxylin-eosin, Cresyl-violet and Van Gieson's method.The specimens from the frontal and temporal lobe showed a fresh focus of malacia in the cortical-subcortical region with beginning macrophage demolition. The greatest accumulation of macrophages was at the border of the cortex and white matter, quite numerous damaged neurons were still visible in the cortex. The walls of small vessels and capillaries presented proliferation of stimulated endothelial and appendage cells. In the occipital lobe, a focus of the older malacia with complete tissue disintegration and advanced macrophage demolition was found. Within the cuneus, the disintegration involved the entire cortex and subcortical regions. The focus was surrounded by a band of loosened white matter with a mast cell reaction. Slightly further, the white matter transitioned to an area of early necrosis with almost complete cellular desolation and only a few macrophages. The lumen of the left middle cerebral artery showed amorphous thrombus masses adjacent to the vessel wall, overgrown with endothelial cells. A focus in the middle temporal cortex, suspected to be of parasitic origin, was observed. However, the surrounding tissue completely lacked any glial or mesodermal reaction, which is not typical of a potential parasitic focus.