Object structure

File of histopathological evaluation of nervous system diseases (1963) - nr 2/63

Institutional creator:

Department of Experimental and Clinical Neuropathology MMRI


Markiewicz, D. dr

Place of publishing:


Date issued/created:



Clinical, anatomical and histological diagnosis

Subject and Keywords:

Vascular diseases - hemorrhages, aneurysms


Histological diagnosis: Haemorrhagia cerebri recens. Arterlosclerosis cerebri gradu magno. Oedema cerebri. Autopsy examination of 80-year-old patient was performed. Neuropathological evaluation in light microscopy was based on brain paraffin sections stained with Hematoxylin-eosin, van Gieson, Heidenhain and Griedley's method.A temporal lobe specimen including three foci, almost exclusively in the white matter, showed multiple circular vascular hemorrhages. Surrounding the hemorrhagic foci, a thinning of the tissue with corresponding fading in staining for myelin, and a reduction in glial elements with simultaneous progressive changes up to mast cell forms of astroglia were seen. In addition, hemosiderin granules were found lying intracellularly and intra-tissue. Diffuse glial proliferation was evident in the periphery of the described lesions. A small hemorrhagic focus formed from fusion of circular perivascular hemorrhages was found in the white matter of the frontal lobe, lateral to the putamen. Increased fibrous and vitreous changes were observed in the putamen and thalamus. In the vicinity of the atherosclerotic lesions, especially in the putamen and thalamus, small perivascular necroses were present. Large cellular defects were seen in the frontal cortex, temporal cortex, basal nuclei, thalamus and hypothalamic nuclei. There were prominent ischemic changes in the cortex and striatum, and large fatty degeneration in the thalamus and hypothalamic nuclei. Prominent features of edema were observed. Hemolyzed blood and hemosiderin granules were present in the meninges and subdural spaces.

Resource type:






Language of abstract:



Creative Commons Attribution BY 4.0 license

Terms of use:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitizing institution:

Mossakowski Medical Research Institute PAS

Original in:

Library of the Mossakowski Medical Research Institute PAS

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.





Citation style: