Object structure

File of histopathological evaluation of nervous system diseases (1963) - nr 7/63

Institutional creator:

Department of Experimental and Clinical Neuropathology MMRI


Kroh, Halina dr med.

Place of publishing:


Date issued/created:



Clinical, anatomical and histological diagnosis

Subject and Keywords:

Vascular disaeses - encephalomacia


Histological diagnosis: Focus encephalomalaciae in reg. nucleorum basalium dextrorum in sta- dio organisationis. Haemorrhagiae punctatae recentes corticis occipitalis. Arteriosclerosis cerebri gradu maiore. Autopsy examination of 56-year-old patient was performed. Neuropathological evaluation in light microscopy was based on brain paraffin sections stained with Hematoxylin-eosin and van Gieson method.The focus of disintegration in the basal nuclei contained numerous macrophages and numerous rod-shaped microglia cells. Capillaries and a network of fibroblasts were infiltrating the focus. Single leukocytes were observed. Towards the periphery, hypertrophied astrocytes were seen. Numerous discrete symptomatic lymphatic infiltrates were seen around the vessels. The walls of capillaries and arterioles were markedly thickened with fibrous and vitreous lesions. Small fresh hemorrhages were found in the occipital cortex. Nerve cells were mostly preserved, but some showed a significant damage. Few scattered leukocytes were visible. The vessels also had small lymphocytic infiltrates. The soft meninges adjacent to the cortex were thickened. Many macrophages were present in the lumen of the vessels in the meninges. In the cerebellum, atrophy of the granular layer of the cortex was observed in several areas. These areas were filled with hypertrophied Bergman's glia. In the Purkinje cell layer, defects and cellular disorders of various types were present. Hemorrhages were found in the granular layer, often separating this layer from the Purkinje cell layer. The small vessels of the cerebellum were also surrounded by infiltrates of single lymphocytes.

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Creative Commons Attribution BY 4.0 license

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Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitizing institution:

Mossakowski Medical Research Institute PAS

Original in:

Library of the Mossakowski Medical Research Institute PAS

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.





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