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Title: File of histopathological evaluation of nervous system diseases (1963) - nr 147/63

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Department of Experimental and Clinical Neuropathology MMRI


Osetowska, Ewa Prof. dr med

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Clinical, anatomical and histological diagnosis


Histological diagnosis: Hydrocephalus internus post meningo ependimitidem. Haemorrhagia subarachnoidealis et oedema cerebri secundarium. Autopsy examination of 5,5-year-old patient was performed. Neuropathological evaluation in light microscopy was based on brain paraffin sections stained with Hematoxylin-eosin, Heidenhain and van Gieson method.The cortex and white matter were pushed to the periphery by the fluid-expanded ventricular system. Moving from the meninges towards the ventricular system, the following changes were found, which were more or less the same at all levels: the meninges were edematous, in some areas extremely thick, with a rich proliferation of collagen fibers. Remnant lymphocytic infiltrates were seen among the fibers and perivascularly. In addition, fresh subarachnoid extravasations were seen, locally taking the form of extensive hemorrhages. The frontal, right occipital cortex was formed normally, but with large cellular atrophy. The white matter was edematous, loosened in structure, with prominent astrocyte proliferation and significant stasis of capillaries and medium-sized vessels. The most characteristic lesions were found in the subependymal area of the temporal horn: several vessels with lymphocytic-plasmacytic infiltrates were found there, as well as two clusters of granulomatous infiltrate passing to the ventricular walls. Along the entire ventricular system, spongiotic necrosis with proliferation of mast cell and fibrous glia was seen. The picture was the evidence of an inflammatory process, most likely a simple purulent bacterial case, which had migrated from the basal meninges to the ependyma, leading to progressive closure of the ventricular system. Subsequently, the inflammatory case healed /the type of infiltration indicates this/, and the hydrocephalus, increasing with scarring, led to a descent with symptoms of edema and hemorrhage.



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Creative Commons Attribution BY 4.0 license

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Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

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Mossakowski Medical Research Institute PAS

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Library of the Mossakowski Medical Research Institute PAS

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Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.



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Feb 1, 2022

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Sep 14, 2021

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Edition name Date
opis nr 147/63 Feb 1, 2022


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