Object structure

File of histopathological evaluation of nervous system diseases (1963) - nr 160/63

Institutional creator:

Department of Experimental and Clinical Neuropathology MMRI


Osetowska, Ewa Prof. dr med

Place of publishing:


Date issued/created:



Clinical, anatomical and histological diagnosis

Subject and Keywords:

Inflammations bacterial


Histological diagnosis: Meningo-encephalitis purulenta metastatica. Haemorrhagia subara- chnoidealis et cerebralis. Histological diagnosis: Meningo-encephalitis purulenta metastatica. Haemorrhagia subara- chnoidealis et cerebralis.Autopsy examination of 13-year-old patient was performed. Neuropathological evaluation in light microscopy was based on brain paraffin sections stained with Hematoxylin-eosin, Heidenhain and van Gieson method.A case with a very complex morphological picture consisting mainly of an inflammatory component and a hemorrhagic component. In addition to the subarachnoid hemorrhage, an extensive hemorrhagic focus was found. The edges of the focus filled by the hematoma were smooth. Longitudinal spongiform necrosis was found at some distance from the focus, particularly in the occipital region. In addition, small circular extrusion hemorrhages were seen in this area. Numerous scattered micro abscesses were observed along the entire cortex, mostly without evident vascular association. In the white matter, these foci were fewer, with only one single foci in the bulb. Mixed purulent-hemorrhagic foci were found in the right temporal lobe and in the meninges of the left Sylvian fossa, with hemorrhage predominating. All vessels had altered, thickened walls with prominent collagen proliferation, often vitrified, with stimulated endothelium. Occasionally, mesodermal organization was evident in the parenchymal hemorrhage. Secondary parenchymal defects.

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Creative Commons Attribution BY 4.0 license

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Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitizing institution:

Mossakowski Medical Research Institute PAS

Original in:

Library of the Mossakowski Medical Research Institute PAS

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.





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