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File of histopathological evaluation of nervous system diseases (1963) - nr 177/63
Institutional creator:Department of Experimental and Clinical Neuropathology MMRI
Contributor: Place of publishing: Date issued/created: Description:Clinical, anatomical and histological diagnosis
Subject and Keywords: Abstract:Histological diagnosis: Glioblastome multiforme.Autopsy examination of 68-year-old patient was performed. Neuropathological evaluation in light microscopy was based on brain paraffin sections stained with Hematoxylin-eosin and van Gieson method.An extremely pleomorphic tumor originating from glial tissue was found. In the central parts it contained numerous necrotic and hemorrhagic foci. In the parts distal to the necrotic lesions, three types of tissue were present: perivascular aggregates, sometimes with astroblastoma-like arrangements; loose structureless aggregates of small, poorly differentiated cells, and occasionally single mast cell astrocytes were seen perivascularly - this part of the tumor resembled the structure of glioma immaturum. The peripheral parts showed accumulations of variously shaped cells, often large hyperchromatic cells, although without clear nuclear conglomerates, and numerous cells with abnormal mitoses, spindle cells and astrocyte-like cells. The tumor transitioned indistinctly into an environment in which tumor cells were shuffled with stimulated glial and with retained neurons.
Resource type: Format: Language: Language of abstract: Rights:Creative Commons Attribution BY 4.0 license
Terms of use:Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -
Digitizing institution:Mossakowski Medical Research Institute PAS
Original in:Library of the Mossakowski Medical Research Institute PAS
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