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File of histopathological evaluation of nervous system diseases (1962) - nr 19/62
Institutional creator:Department of Experimental and Clinical Neuropathology MMRI
Contributor: Place of publishing: Date issued/created: Description:Clinical, anatomical and histological diagnosis
Subject and Keywords:Inflammations ; Brain - inflammations
Abstract:Histological diagnosis: Encephalitis lymphocytaria acuta.Autopsy examination of 14-month-old patient was performed. Neuropathological evaluation in light microscopy was based on brain paraffin sections stained with Hematoxylin-eosin and Heidenhain method. Heidenhain staining showed small perivascular foci of myelin fading in the white matter of the hemispheres, in the cerebellum, and in the brainstem. These foci at high magnification corresponded to fields of dissection and fragmentation of myelin sheaths. Predominantly in the white matter of the hemispheres, and to a lower extent in the brainstem and cerebellum, numerous vessels with discrete lymphocytic infiltrates were observed. The astrocytic glia were stimulated, concentrated. Several more severely infiltrated vessels were seen in the basal ganglia, thalamus. Patches of proliferating microglia were seen near the ventricular system. Cortical capillaries were stimulated, often with small infiltrates - loose lymphocytic infiltrates in the meninges. Significant diffuse ischemic changes were observed in the thalamus and altered Purkinje cells and dentate nucleus in the cerebellum.
Resource type: Format: Language: Language of abstract: Rights:Creative Commons Attribution BY 4.0 license
Terms of use:Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -
Digitizing institution:Mossakowski Medical Research Institute PAS
Original in:Library of the Mossakowski Medical Research Institute PAS
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