Object structure

File of histopathological evaluation of nervous system diseases (1962) - nr 225/62

Institutional creator:

Department of Experimental and Clinical Neuropathology MMRI


E.Osetowska, dr hab.

Place of publishing:


Date issued/created:



Clinical, anatomical and histological diagnosis

Subject and Keywords:

Encephalopathia & Myelopathia


Autopsy examination of 57-year-old patient was performed. Neuropathological evaluation in light microscopy was based on brain paraffin sections stained with Hematoxylin-eosin, van Gieson and Heidenhein method.The atrophic and degenerative changes were scattered throughout the brain. The cerebral cortex of the frontal and occipital regions was extremely thinned to the point of obliteration of the layered pattern. Individual cells showed ischemic and sclerotic changes. In the basal ganglia, nucleus accumbens and cerebellar neurons, degeneration due to lipopigment accumulation predominated. In the nucleus dentatus, sclerotic lesions were predominant; neurons of this nucleus were prominently atrophied. In the cerebellar cortex, thinning in the granular layer was observed, in one lobe cortical atrophy suggesting local circulatory disorders was seen. A small focus of malacia in the white matter was observed in the frontal region. Alzheimer's glia in the form of naked nuclei was very abundant throughout the brain. Bargmann's glia was observed in the cerebellum. Disintegrated cells of substance nigra were very abundant. Relatively abundant pseudo-calcium deposits were found in the vessel walls and lying free endothelially in the globus pallidus. Histological diagnosis: Glia hepaticum. Atrophia corticis. Focus encephalomalaciae parvus reg. frontalis. Atrophia granularis incipiens cerebelli.

Resource type:






Language of abstract:



Creative Commons Attribution BY 4.0 license

Terms of use:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitizing institution:

Mossakowski Medical Research Institute PAS

Original in:

Library of the Mossakowski Medical Research Institute PAS

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.





Citation style: