Title:

CHANGES IN THE ACTIVITY OF ALKALINE PHOSPHATASE AND ADENYLATE CYCLASE IN THE BRAIN VASCULAR NETWORK IN EXPERIMENTAL POSTRESUSCITATION SYNDROME

Creator:

Szumańska, G. ; Mossakowski, Mirosław Jan (1929–2001) ; Januszewski, Sławomir

Publisher:

Zakład im. Ossolińskich - Wydawnictwo Polskiej Akademii Nauk

Place of publishing:

Wrocław ; Warszawa ; Kraków

Date issued/created:

1988

Type of object:

Journal/Article

Subject and Keywords:

alkaline phosphatase ; adenyl cyclase activity ; brain ; post-resuscitation syndrom

Abstract:

Activity of alkaline phosphatase and adenylate cyclase was evaluated in the brain vascularnetwork of rats subjected to 10 min clinical death due to cardiac arrest.Progressive decrease of both enzymes activities was noted in the early survival stages, reachingthe lowest intensity in 24th h after ischemic incident. Restitution of enzymatic activity was observed2 days later, although even then it did not reach intensity typical for normal controls. Electronmicroscopic study revealed disturbances of normal polarity of enzyme distribution in thecytoplasmic membranes of vascular endothelia. Activity of enzymes disappeared from luminalendothelial surfaces, appearing on abluminal ones and in the capillary basal membranes.Ultrastructural picture of the cerebral capillaris was additionally characterized by remarkableincrease of micropinocytic vesicles, and appearance of coated vesicles as well as canalicularstructures. Swelling of endothelial cytoplasm and widening of interendothelial clefts were alsopresent.The results obtained indicate that deep 10 min ischemia in experimentally induced clinicaldeath is leading to the impairment of transport functions in damaged cerebral capillaryvessels.

Relation:

Neuropatologia Polska

Volume:

26

Issue:

3

Start page:

335

End page:

357

Resource type:

Text

Detailed Resource Type:

Article

Format:

pdf

Language:

pol

Language of abstract:

eng ; rus

Rights:

Creative Commons Attribution BY 4.0 license

Terms of use:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitizing institution:

Mossakowski Medical Research Institute PAS

Original in:

Library of the Mossakowski Medical Research Institute PAS

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open