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Perspectives for Medicinal Applications of Synthetic Oligonucleotides: Antisense Technology
Subtitle:Perspectives for Medicinal Applications of Synthetic Oligonucleotides: Antisense Technology
Creator:Stec, Wojciech J. ; Guga, Piotr
Publisher:Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS
Date issued/created: Description: Subject and Keywords: Abstract:Pharmaceutical industry is entering the era of “chirotechnology revolution”: in many countriesjany potential drug containing asymmetry centres has to be tested in its stereochemically pureforms. In the authors’ laboratory many efforts have been made, with a certain extent of success,to stereocontrolled chemical synthesis of oligonucleoside phosphorothioates and methanephosphonates. Stability of stereoregular oligonucleotides towards selected nucleases, as well as thethermal stability of duplexes formed with DNA and RNA were investigated. Other strategiesleading to antisense oligonucleotides try to avoid P-chirality by replacement of phosphates withachiral phosphorodithioates or moieties like formacetal, sulphones, diethylsilo.xanes etc.
Relation:Biotechnologia, vol.35, 4 (1996)-.
Volume: Issue: Start page: End page: Resource type: Detailed Resource Type: Format: Resource Identifier: Source:Library of Institute of Bioorganic Chemistry PAS
Language: Language of abstract: Temporal coverage: Rights:Creative Commons Attribution BY-SA 4.0 license
Terms of use: Digitizing institution:Institute of Bioorganic Chemistry of the Polish Academy of Science
Original in:Institute of Bioorganic Chemistry of the Polish Academy of Science
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